אני אל שדי. The commandment of circumcision was given using this Divine Name (El Shaddai) because a man's strength and power are diminished through circumcision. As our Sages have taught, יצפון לישרים תושיה (Proverbs 2:7), "He treasures up sound wisdom for the righteous," refers to circumcision, which the Holy One, Blessed be He, concealed for twenty generations, from Adam until Abraham. This name, Shaddai, is associated with power, as it is written, כקול מים רבים כקול שדי (Ezekiel 1:24), "like the voice of many waters, like the voice of Shaddai." G-d did not want Abraham to think that by cutting his flesh he would weaken himself and make himself vulnerable to his enemies. Therefore, G-d said to him, אני אל שדי, “I am El Shaddai.” I will provide you with the strength and power to overcome your enemies, both you and all your circumcised descendants. This echoes Rabbeinu Chananel's commentary, which emphasizes that the name Shaddai, associated with might and strength, was used to reassure Abraham that despite the physical act of circumcision, G-d would ensure his continued strength and ability to overcome adversaries. This reassurance extended to all of Abraham's descendants who would observe this commandment.

ולישמעאל שמעתיך ... ונתתיו לגוי גדולת. We see from our historical records that this prophecy came true after a delay of 2333 years. [Avraham was circumcised in the year 2047 according to Seder hadorot and the Mohammedan faith originated in the year 4384, exactly 2333 years later.] This delay was not due to sins of the original Ishmaelites. They had been looking forward to the fulfillment of this prophecy for all these years. We lost our independence due to our sins, however. G'd set a time of 1305 years (according to Daniel) until our redeemer would come. We must certainly continue to look forward to our glorious destiny and not despair if the Ishmaelites had not despaired after over 2000 years (Rabbeinu Bachya).