דמיו בו, his blood is on his own head. He made himself guilty of the death penalty.

את אשת רעהו, excluding if he slept with a “wife” who was a gentile. The adulterer would then not face the death penalty.

חסד הוא, the word חסד here is to be understood in the same sense as the same word in Proverbs 25,10 פן יחסדך שומע, “lest the one who hears it puts you to shame.” We also find the word having such a meaning in Proverbs 14,34 וחסד לאומים חטאת, “even the kindness of nations is a form of sin.” This is also the way Rav Yoseph translates this word in his commentary on Proverbs.

ערירים ימותו , Heaven will interfere with such couples’ ability to conceive and to give birth to viable children.